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However, chloroquine common adverse effects in a randomised, placebo-controlled trial in which carbamazepine was administered for 2-4 weeks before benzodiazepine tapering over 4 weeks to 40 patients who had previous difficulties in withdrawing from therapeutic dose benzodiazepines, there were no significant differences from placebo in severity of withdrawal symptoms or outcome at 12 weeks' post-withdrawal (Schweizer et al, 1991).